Anti-tumor pharmacology of natural products targeting mitosis

作     者：Manru Huang Caiyan Liu Yingying Shao Shiyue Zhou Gaoyong Hu Shuangshuang Yin Weiling Pu Haiyang Yu Manru Huang;Caiyan Liu;Yingying Shao;Shiyue Zhou;Gaoyong Hu;Shuangshuang Yin;Weiling Pu;Haiyang Yu

作者机构：Key Laboratory of Pharmacology of Traditional Chinese Medical FormulaeMinistry of EducationTianjin University of Traditional Chinese MedicineTianjin 301617China State Key Laboratory of Component-based Chinese MedicineTianjin University of Traditional Chinese MedicineTianjin 301617China 

出 版 物：《Cancer Biology & Medicine》 (癌症生物学与医学（英文版）)

年 卷 期：2022年第19卷第6期

页      面：774-801页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was supported by the National Key Research and Development Program of China(Grant No:2021YFE0203100) National Natural Science Foundation of China(Grant Nos:81873089,81603253 and 81973570) Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(Grant No:ZYYCXTD-C-202009) Innovation Team and Talents Cultivation Program ofNational Administration ofTraditional Chinese Medicine(Grant No:ZYYCXTD-D-202002) 

主　　题：Tumor mitosis natural products mechanism pharmacology 

摘      要：Cancer has been an insurmountable problem in the history of medical *** uncontrollable proliferation of cancer cells is one of cancers main characteristics,which is closely associated with abn ormal *** mitosis is an effective method for cancer *** review summarizes several natural products with anti-tumor effects related to mitosis,focusing on targeting microtubulin,inducing DNA damage,and modulating mitosis-associated ***,the main disadvantages of several typical compounds,including drug resistance,toxicity to non-tumor tissues,and poor aqueous solubility and pharmacokinetic properties,are also discussed,together with strategies to address *** understanding of cancer cell mitosis and natural products may pave the way to drug development for the treatment of cancer.