Role of high mobility group box protein 1 in depression:A mechanistic and therapeutic perspective
作者机构：Department of NeurosurgeryBeijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Department of NeurosurgerySanbo Brain HospitalCapital Medical UniversityBeijing 100093China Beijing Key Laboratory of EpilepsyCenter of EpilepsyBeijing Institute of Brain DisordersCollaborative Innovation Center for Brain DisordersCapital Medical UniversityBeijing 100093China Department of CardiologyShandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of NeurologyShandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina
出 版 物：《World Journal of Psychiatry》 (世界精神病学杂志)
年 卷 期：2022年第12卷第6期
页 面：779-786页
核心收录：
学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学]
主 题：Neuroinflammation Depression High mobility group box 1 Mechanism Review Perspective
摘 要：As a common and serious psychiatric disorder,depression significantly affects psychosocial functioning and quality of ***,the mechanism of depression is still enigmatic and perplexing,which limits its precise and effective therapeutic *** studies demonstrated that neuroinflammation activation plays an important role in the pathophysiology of *** this respect,high mobility group box 1(HMGB1)may be a possible signaling inducer of neuroinflammation and can be a potential mechanistic and therapeutic target for ***,we review recent studies on the mechanistic and therapeutic targets of HMGB1 in depression and propose potential perspectives on this topic.
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