Disrupted leptin-fatty acid biosynthesis is an early manifestation of metabolic abnormalities in schizophrenia

作     者：Mohammad M Khan 

作者机构：Laboratory of Translational Neurology and Molecular PsychiatryDepartment of BiotechnologyEra's Lucknow Medical College and Hospitaland Faculty of ScienceEra UniversityLucknow 226003India Department of Psychiatry and Health BehaviorMedical College of GeorgiaAugusta UniversityAugustaGA 30912United States 

出 版 物：《World Journal of Psychiatry》 (世界精神病学杂志)

年 卷 期：2022年第12卷第6期

页      面：827-842页

核心收录：

学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学] 

主　　题：Schizophrenia Leptin Fatty acids Insulin resistance Impaired energy expenditure 

摘      要：BACKGROUND Insulin resistance(IR)and impaired energy expenditure(IEE)are irreparable metabolic comorbidities in *** mechanism(s)underlying IR and IEE remains unclear,leptin and fatty acid signaling,which has profound influence on insulin secretion/sensitivity,glucose metabolism and energy expenditure,could be ***,no association of plasma leptin with erythrocyte membrane fatty acids,body mass index(BMI),and psychotic symptoms in the same cohort of untreated patients with first-episode psychosis(FEP)or medicated patients with chronic schizophrenia(CSZ)is presented *** studies are crucial for deciphering the role of leptin and fatty acids in the development of IR and IEE in *** To determine the association between plasma leptin,erythrocyte membrane fatty acids,particularly,saturated fatty acids(SFAs),BMI and psychotic symptoms in patients with FEP and *** In this study,twenty-two drug naive patients with FEP,twenty-one CSZ patients treated with atypical antipsychotic drugs,and fourteen healthy control(CNT)subjects were *** leptin was measured using sandwich mode enzyme-linked immunosorbent *** membrane SFAs were measured using ultrathin capillary gas *** was calculated by using the formula:weight(kg)/height(m^(2)).Psychiatric symptoms were evaluated at baseline using brief psychiatric rating scale(BPRS),and positive and negative syndrome scale(PANSS).The total BPRS scores,positive and negative symptom scores(PANSS-PSS and PANSS-NSS,respectively)were *** correlation coefficient(r)analyses were performed to find the nature and strength of association between plasma leptin,PANSS scores,BMI and SFAs,particularly,palmitic acid(PA).RESULTS In patients with FEP,plasma leptin not BMI was significantly lower(P=0.034),whereas,erythrocyte membrane SFAs were significantly higher(P0.005)compared to the CNT ***,plasma leptin showed negative correlation