The association between heavy metal exposure and erectile dysfunction in the United States

作     者：Wei Wang Li-Yuan Xiang Yu-Cheng Ma Jia-Wei Chen Liao Peng Xiao-Shuai Gao Fu-Xun Zhang Yang Xiong Feng Qin Jiu-Hong Yuan 

作者机构：Andrology LaboratoryWest China HospitalSichuan UniversityChengdu 610041China Department of UrologyInstitute of UrologyWest China HospitalSichuan UniversityChengdu 610041China Department of Clinical Research ManagementWest China HospitalSichuan UniversityChengdu 610041China 

出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)

年 卷 期：2023年第25卷第2期

页      面：271-276页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：This work was supported by the Natural Science Foundation of China(No.81871147 and No.82071639) the Sichuan Science and Technology Program(No.2022YFS0028 and No.2022YFS0134) 

主　　题：erectile dysfunction heavy metals National Health and Nutrition Examination Survey 

摘      要：Literature regarding the impacts of heavy metal exposure on erectile dysfunction(ED)is *** aimed to evaluate the correlation between 10 urinary metals and ED in a large,nationally representative adult male *** dataset was extracted from the National Health and Nutrition Examination Survey(NHANES)during the period of 2001–2002 and 2003–*** proportions and multivariable logistic regression analysis adjusted for confounding variables were utilized to determine the relationship between metal exposure and *** quantile sum(WQS)regression was utilized to evaluate the impact of a mixture of urinary metals on ED.A total of 1328 participants were included in our *** multivariable logistic regression analysis,cobalt(Co)and antimony(Sb)were positively associated with ED(odds ratio[OR]:1.36,95%confidence interval[CI]:1.10–1.73,P=0.020;and OR:1.41,95%CI:1.12–1.77,P=0.018,respectively)after full *** in tertile 4 for Co(OR:1.49,95%CI:1.02–2.41,P for trend=0.012)and Sb(OR:1.53,95%CI:1.08–2.40,P for trend=0.041)had significantly higher odds of ED than those in tertile ***,the WQS index was significantly linked with increased odds of ED after full adjustment(OR:1.31,95%CI:1.04–1.72,P0.05).Our study expanded on previous literature indicating the possible role of heavy metal exposure in the etiology of *** evaluation of heavy metal exposure should be included in the risk assessment of ED.