High‑Performance Flexible Microneedle Array as a Low‑Impedance Surface Biopotential Dry Electrode for Wearable Electrophysiological Recording and Polysomnography

作     者：Junshi Li Yundong Ma Dong Huang Zhongyan Wang Zhitong Zhang Yingjie Ren Mengyue Hong Yufeng Chen Tingyu Li Xiaoyi Shi Lu Cao Jiayan Zhang Bingli Jiao Junhua Liu Hongqiang Sun Zhihong Li Junshi Li;Yundong Ma;Dong Huang;Zhongyan Wang;Zhitong Zhang;Yingjie Ren;Mengyue Hong;Yufeng Chen;Tingyu Li;Xiaoyi Shi;Lu Cao;Jiayan Zhang;Bingli Jiao;Junhua Liu;Hongqiang Sun;Zhihong Li

作者机构：National Key Laboratory of Science and Technology on Micro/Nano FabricationSchool of Integrated CircuitsPeking UniversityBeijing 100871People’s Republic of China Peking University Sixth HospitalPeking University Institute of Mental HealthNHC Key Laboratory of Mental Health(Peking University)National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital)Beijing 100191People’s Republic of China School of ElectronicsPeking UniversityBeijing 100871People’s Republic of China Hypnometry MicrosystemBeijing 100871People’s Republic of China College of EngineeringPeking UniversityBeijing 100871People’s Republic of China 

出 版 物：《Nano-Micro Letters》 (纳微快报（英文版）)

年 卷 期：2022年第14卷第8期

页      面：142-163页

核心收录：

学科分类：081704[工学-应用化学] 08[工学] 0817[工学-化学工程与技术] 081201[工学-计算机系统结构] 0812[工学-计算机科学与技术（可授工学、理学学位）] 

基　　金：supported by the China Capital Health Research and Development of Special (No. 2018-14111) the National Natural Science Foundation of China (grant No. 62004007 and No. 82027805) the China Postdoctoral Science Foundation Grant (No. 2021M700258) 

主　　题：Flexible microneedle array Dry electrode Low-impedance electrode–skin contact Wearable wireless electrophysiological recording Polysomnography 

摘      要：Microneedle array(MNA)electrodes are an effective solution to achieve high-quality surface biopotential recording without the coordination of conductive gel and are thus very suitable for long-term wearable *** schemes are limited by flexibility,biosafety,and manufacturing costs,which create large barriers for wider ***,we present a novel flexible MNA electrode that can simultaneously achieve flexibility of the substrate to fit a curved body surface,robustness of microneedles to penetrate the skin without fracture,and a simplified process to allow mass *** compatibility with wearable wireless systems and the short preparation time of the electrodes significantly improves the comfort and convenience of electrophysiological *** normalized electrode–skin contact impedance reaches 0.98 kΩcm^(2)at 1 kHz and 1.50 kΩcm^(2)at 10 Hz,a record low value compared to previous reports and approximately 1/250 of the standard *** morphology,biosafety,and electrical/mechanical properties are fully characterized,and wearable recordings with a high signal-to-noise ratio and low motion artifacts are *** first reported clinical study of microneedle electrodes for surface electrophysiological monitoring was conducted in tens of healthy and sleep-disordered subjects with 44 nights of recording(over 8 h per night),providing substantial evidence that the electrodes can be leveraged to substitute for clinical standard electrodes.