Patient-directed ***-volume PEG for colonoscopy preparation:a randomized controlled trial

作     者：Jixiang Zhang Xuemei Jia Yuanmei Guo Haotian Jiang Jiaming Hu Siwei Wang Binglu Huang Wenhao Su Jun Liu Xiaoli Wang Weiguo Dong 

作者机构：Department of GastroenterologyRenmin Hospital of Wuhan UniversityWuhan 430060China Digestive Endoscopy CenterRenmin Hospital of Wuhan UniversityWuhan 430060China Department of HematologyHuashan Hospital of Fudan UniversityShanghai 200433China Department of HematologyRenmin Hospital of Wuhan UniversityWuhan 430060China Department of Plastic SurgeryRenmin Hospital of Wuhan UniversityWuhan 430060China 

出 版 物：《Precision Clinical Medicine》 (精准临床医学（英文）)

年 卷 期：2022年第5卷第2期

页      面：117-124页

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported from the National Natural Science Foundation of China(Grants No.82000521 and 82102797) 

主　　题：bowel preparation patient-directed individualization efficacy safety 

摘      要：Background:Individualization using different volumes of polyethylene glycol is widely regarded as the optimal solution for bowel preparation,while the patient-directed regimen we propose may serve as a reliable individual *** study aimed to assess the efficacy,safety,and satisfaction of bowel preparation with a patient-directed ***:Patients in the fixed-volume group ingested the same amount of PEG,while those in patient-directed group ingested different amount according to stool consistency or stool water ***:After filtering by exclusion criteria,428 individuals in the fixed-volume group and 103 in the patient-directed group were successfully enrolled and ***-three(80.6%)individuals in the patient-directed group had a reduced polyethylene glycol *** was no significant difference in the bowel preparation efficacy between the two groups(90.0%vs.90.3%,χ^(2)=0.01;p=0.918).Patients in the patient-directed group complained of fewer adverse effects(53.0%vs.36.9%,χ^(2)=8.655;p=0.003),especially vomiting(13.6%vs.1.0%,χ^(2)=13.304;p0.001).Regarding comfort during bowel preparation,the degree of comfort was not significantly different between ***,the willingness rate for further colonoscopy in the patient-directed group was significantly higher than that in the fixed-volume group(90.3%vs.77.1%,χ^(2)=8.912;p0.05).Multivariable logistic regression analysis showed that the body mass index served as an independent factor impacting quality of bowel preparation with the patient-directed regimen(OR 1.16,95%CI 1.00–1.34;p=0.043).Conclusions:Without decreasing the bowel preparation efficacy,the patient-directed regimen increased the safety and satisfaction of bowel preparation and is expected to be a regular and individual solution for bowel *** with a lower body mass index are more likely to undertake this new regimen.