Integrated metabolism and epigenetic modifications in the macrophages of mice in responses to cold stress

作     者：Jingjing LU Shoupeng FU Jie DAI Jianwen HU Shize LI Hong JI Zhiquan WANG Jiahong YU Jiming BAO Bin XU Jingru GUO Huanmin YANG Jingjing LU;Shoupeng FU;Jie DAI;Jianwen HU;Shize LI;Hong JI;Zhiquan WANG;Jiahong YU;Jiming BAO;Bin XU;Jingru GUO;Huanmin YANG

作者机构：College of Animal Science and Veterinary MedicineHeilongjiang Bayi Agricultural UniversityDaqing163319China College of Veterinary MedicineJilin UniversityChangchun130062China Shanghai Bioprofile Co.Ltd.Shanghai201100China Faculty of AgriculturalLife and Environmental SciencesUniversity of AlbertaEdmontonAlbertaT5J 4P6Canada 

出 版 物：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 (浙江大学学报（英文版）B辑（生物医学与生物技术）)

年 卷 期：2022年第23卷第6期

页      面：461-480页

核心收录：

学科分类：0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 0836[工学-生物工程] 10[医学] 

基　　金：the National Natural Science Foundation of China(Nos.31672513 and 31772695) the Heilongjiang Provincial Natural Science Foundation of China(No.YQ2021C027) the Key Program of Natural Science Foundation of Heilongjiang Province(No.ZD2019C004) the Heilongjiang Bayi Agricultural University for San Heng San Zong(No.ZRCQC202003),China。 

主　　题：Low temperature Stress Autophagy Metabolic reprogramming Histone 

摘      要：The negative effects of low temperature can readily induce a variety of diseases.We sought to understand the reasons why cold stress induces disease by studying the mechanisms of fine-tuning in macrophages following cold exposure.We found that cold stress triggers increased macrophage activation accompanied by metabolic reprogramming of aerobic glycolysis.The discovery,by genome-wide RNA sequencing,of defective mitochondria in mice macrophages following cold exposure indicated that mitochondrial defects may contribute to this process.In addition,changes in metabolism drive the differentiation of macrophages by affecting histone modifications.Finally,we showed that histone acetylation and lactylation are modulators of macrophage differentiation following cold exposure.Collectively,metabolism-related epigenetic modifications are essential for the differentiation of macrophages in cold-stressed mice,and the regulation of metabolism may be crucial for alleviating the harm induced by cold stress.