Role of cannabinoids and the endocannabinoid system in modulation of diabetic cardiomyopathy
作者机构：Department of Pharmacology and ToxicologyFaculty of PharmacySuez Canal UniversityIsmailia 41522Egypt Program of BiochemistryMcMaster UniversityHamilton L8S 4L8OntarioCanada Department of Pharmacology and BiochemistryDelta University for Science and TechnologyMansoura 35511New CairoEgypt
出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)
年 卷 期：2022年第13卷第5期
页 面：387-407页
核心收录：
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学]
主 题：Δ9-tetrahydrocannabinol Autophagy Cannabinoid receptors Diabetic cardiomyopathy Endocannabinoid system Inflammation
摘 要：Diabetic complications,chiefly seen in long-term situations,are persistently deleterious to a large extent,requiring multi-factorial risk reduction strategies beyond glycemic *** cardiomyopathy is one of the most common deleterious diabetic complications,being the leading cause of mortality among diabetic *** mechanisms of diabetic cardiomyopathy are multi-factorial,involving increased oxidative stress,accumulation of advanced glycation end products(AGEs),activation of various pro-inflammatory and cell death signaling pathways,and changes in the composition of extracellular matrix with enhanced cardiac *** novel lipid signaling system,the endocannabinoid system,has been implicated in the pathogenesis of diabetes and its complications through its two main receptors:Cannabinoid receptor type 1 and cannabinoid receptor type 2,alongside other ***,the role of the endocannabinoid system in diabetic cardiomyopathy has not been fully *** review aims to elucidate the possible mechanisms through which cannabinoids and the endocannabinoid system could interact with the pathogenesis and the development of diabetic *** mechanisms include oxidative/nitrative stress,inflammation,accumulation of AGEs,cardiac remodeling,and autophagy.A better understanding of the role of cannabinoids and the endocannabinoid system in diabetic cardiomyopathy may provide novel strategies to manipulate such a serious diabetic complication.
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