Lanthanide-DNA supramolecular hydrogels with tunable and responsive luminescence

作     者：YANG Sen PAN XiaoRui TANG JianPu YAO Chi YANG DaYong YANG Sen;PAN XiaoRui;TANG JianPu;YAO Chi;YANG DaYong

作者机构：Frontiers Science Center for Synthetic BiologyKey Laboratory of Systems Bioengineering(MOE)Institute of Biomolecular and Biomedical EngineeringSchool of Chemical Engineering and TechnologyTianjin UniversityTianjin300350China 

出 版 物：《Science China(Technological Sciences)》 (中国科学（技术科学英文版）)

年 卷 期：2022年第65卷第5期

页      面：1043-1051页

核心收录：

学科分类：0710[理学-生物学] 081702[工学-化学工艺] 08[工学] 0817[工学-化学工程与技术] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

基　　金：supported in part by Tianjin Natural Science Foundation(Basic Research Plan Grant Nos.18JCJQJC47600 and 19JCQNJC02200)。 

主　　题：DNA hydrogel supramolecular self-assembly luminescent hydrogel lanthanide complex stimuli-responsiveness 

摘      要：Supramolecular DNA hydrogels have been synthesized based on the assembly of DNA building-blocks such as branched DNA and long DNA chains.The structures and functions of sole-module DNA hydrogels remain limitations.New methodologies by integrating hybrid components are desired to expand the synthesis of DNA hydrogel.Herein,we synthesized a Ln^(3+)-containing luminescent supramolecular hydrogel by employing the coordination and electrostatic interactions between lanthanide ions(Tb^(3+)and Eu^(3+))and linear single-stranded DNA(ssDNA).Through the coordination between ssDNA and Ln^(3+),a series of luminescent supramolecular hydrogels were synthesized,among which the Tb-G_(n)/T_(n)and Eu-T_(n)hydrogels emitted the characteristic luminescence of Tb and Eu,respectively.The luminescent intensities of the hydrogels were adjusted by designing DNA sequences with programmable bases and chain lengths.Notably,the Tb/Eu co-doped luminescent supramolecular hydrogel displayed tunable luminescence from green to yellow by regulating the stoichiometric ratio of Tb/Eu.Moreover,the hydrogel had reversible luminescent stimulation responsiveness toward Ag^(+)/L-Cys.We expected that the synthesis of Ln^(3+)-containing luminescent supramolecular hydrogels enriched the strategies of the construction of DNA hydrogels,and promoted the development of stimuli-responsive supramolecular materials.