Comparative efficacy and safety of adenosine and regadenoson for assessment of fractional flow reserve:A systematic review and meta-analysis

作     者：Gauravpal Singh Gill Akshaya Gadre Arun Kanmanthareddy 

作者机构：Cardiovascular MedicineCreighton University School of MedicineOmahaNE 68124United States Internal MedicineWestern Michigan University Homer Stryker MD School of MedicineKalamazooMI 49007United States 

出 版 物：《World Journal of Cardiology》 (世界心脏病学杂志（英文版）（电子版）)

年 卷 期：2022年第14卷第5期

页      面：319-328页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Adenosine Regadenoson Fractional flow reserve Meta-analysis 

摘      要：BACKGROUND Adenosine is a coronary hyperemic agent used to measure invasive fractional flow reserve(FFR)of intermediate severity coronary *** To compare FFR assessment using adenosine with an alternate hyperemic agent,*** PubMed,Google Scholar,CINAHL and Cochrane databases were queried for studies comparing adenosine and regadenoson for assessment of *** on FFR,correlation coefficient and adverse events from the selected studies were extracted and analyzed by means of random effects *** tailed P-value less than 0.05 was considered *** was assessed using I2 *** Five studies with 248 patients were included in the final *** included patients and coronary lesions underwent FFR assessment using both adenosine and *** was no significant mean difference between FFR measurement by the two agents[odds ratio(OR)=-0.00;95%confidence interval(CI):(-0.02)-0.01,P=0.88].The cumulative correlation coefficient was 0.98(0.96-0.99,P0.01).Three of five studies reported time to FFR with cumulative results favoring regadenoson(mean difference 34.31 s;25.14-43.48 s,P0.01).Risk of adverse events was higher with adenosine compared to regadenoson(OR=2.39;95%CI:1.22-4.67,P=0.01),which most commonly included bradycardia and *** majority of the adverse events associated with both agents were *** The performance of regadenoson in inducing maximal hyperemia was comparable to that of *** was excellent correlation between the FFR measurements by both the *** use of adenosine,was however associated with higher risk of adverse events and longer time to FFR compared to regadenoson.