Can Plasmodium falciparum Induce Homocysteinemia in Malaria Patients?

作     者：Noé Yaméogo Abdoul Karim Ouattara Bapio Valérie Bazié Alfred Rakissida Ouédraogo Florencia Wendkuuni Djigma Jacques Simporé Noé Yaméogo;Abdoul Karim Ouattara;Bapio Valérie Bazié;Alfred Rakissida Ouédraogo;Florencia Wendkuuni Djigma;Jacques Simporé

作者机构：Laboratoire de Biologie Moléculaires et de Génétique (LABIOGENE) UFR-SVT Université Joseph KI-ZERBO Ouagadougou Burkina Faso Centre Hospitalier Universitaire de Bogodogo Ouagadougou Burkina Faso Centre de Recherche Biomoléculaire Pietro Annigoni (CERBA) Ouagadougou Burkina Faso Université Norbert Zongo (UNZ) Centre Universitaire de Manga Koudougou Burkina Faso Centre National de Recherche Scientifique et Technologique Ouagadougou Burkina Faso UFR-SDS Université Joseph KI-ZERBO Ouagadougou Burkina Faso 

出 版 物：《Journal of Biosciences and Medicines》 (生物科学与医学（英文）)

年 卷 期：2022年第10卷第5期

页      面：117-128页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Homocysteine Malaria Burkina Faso 

摘      要：Background: Plasmodium falciparum has developed elaborate strategies to survive in the hostile intracellular environment of the infected host cell, including resistance to oxidative stress. Cysteine is a metabolic product of homocysteine and a precursor of the antioxidant glutathione used by Plasmodium falciparum to escape harmful oxidation. Objectives: In the present study we aimed to assess whether Plasmodium falciparum can induce homocysteinemia in malaria patients of Burkina Faso. Methods: Eighty-five (85) individuals including 25 affected by severe malaria, 44 by simple malaria, and 12 negative controls for P. falciparum infection were included in the present study. An enzymatic assay of plasma homocysteinemia was performed using the Homocysteine Enzymatic Assay reagent (ref 05385415 190) on the Roche/ Hitachi Cobas c. Results: The results of the present study show that the mean plasma homocysteine concentrations were 15.1 ± 8.4 μmol/L among patients with severe malaria, 14.0 ± 6.0 μmol/L in patients with uncomplicated malaria, and 12.6 ± 4.1 μmol/L in negative controls for malaria parasite. Conclusions: Our findings suggest high homocysteinemia in malaria patients, especially in those with severe malaria. Monitoring homocysteinemia in the latter group will be useful to avoid complications when an elevated plasma level of homocysteine is a known risk factor for cardiovascular diseases.