Genetic and phenotypic heterogeneity in tropical calcific pancreatitis

作     者：Sumit Paliwal Seema Bhaskar Giriraj R Chandak 

作者机构：CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB)Hyderabad 500007India Adjunct Group LeaderGenome Institute of SingaporeBiopolis 138672Singapore 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2014年第20卷第46期

页      面：17314-17323页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：support from the Council of Scientific and Industrial Research,Indian Council of Medical Research Department of Biotechnology,Government of India,India 

主　　题：Chronic pancreatitis Tropical calcific pancreatitis Fibrocalculous pancreatic diabetes Clinical phenotype Genetic risk factors 

摘      要：Tropical calcific pancreatitis(TCP)is a form of chronic non-alcoholic pancreatitis initially reported in the developing parts of the tropical *** clinical phenotype of TCP has undergone marked changes since its first description in *** disease is now seen in relatively older people with less severe *** addition,there are varying reports on the proportion of cases presenting with imaging abnormalities like calcification,ductal dilation,and glandular *** progress has also been made in understanding the etiopathology of *** role of malnutrition and cassava toxicity in its pathogenesis is disproven and few studies have focused on the role of micronutrient deficiency and oxidative stress in the etiopathogenesis of *** evidence support an important role for genetic risk factors in *** studies have shown that,rather than mutations in trypsinogens,variants in serine protease inhibitor kazal type 1,cathepsin B,chymotrypsin C,cystic fibrosis transmembrane regulator,and carboxypeptidase A1,predict risk of *** studies also provided evidence of mutational heterogeneity between TCP and chronic pancreatitis in Western *** current review summarizes recent advances that have implications in the understanding of the pathophysiology and thus,heterogeneity in genotype-phenotype correlations in TCP.