大部分海马硬化性痴呆患者可表现为额颞性痴呆
Most cases of dementia with hippocampal sclerosis may represent frontotemporal dementia作者机构：Department of Pathology UT Southwestern Medical School 5323 Harry Hines Blvd. Dallas TX 75390- 9073 United States Dr.
出 版 物：《世界核心医学期刊文摘（神经病学分册）》 (Digest of the World Core Medical Journals:Clinical Neurology)
年 卷 期：2005年第1卷第1期
页 面：56-56页
学科分类：1002[医学-临床医学] 100203[医学-老年医学] 10[医学]
主 题：额颞性痴呆 硬化性 运动神经元病 变异型 例生 不可溶性 包涵体 尸检结果 机能紊乱 发病机制
摘 要：Hippocampal sclerosis dementia (HSD) is a disease of unknown etiology and pathogenesis. To determine whether HSD cases could be reclassified as variants of frontotemporal dementia (FTD), a heterogeneous group of disorders, 18 brain autopsy cases previously diagnosed as HSD were re evaluated. In 11 cases, ubiquitinated neuronal inclusions, similar to those of motor neuron disease inclusion dementia (MNDID), were found. Brain levels of soluble and insoluble tau were normal. Most patients with pathologic findings of HSD may actually have the MNDID variant of FTD.
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