Review on acute pancreatitis attributed to COVID-19 infection

作     者：Takumi Onoyama Hiroki Koda Wataru Hamamoto Shiho Kawahara Yuri Sakamoto Taro Yamashita Hiroki Kurumi Soichiro Kawata Yohei Takeda Kazuya Matsumoto Hajime Isomoto 

作者机构：Division of Gastroenterology and NephrologyDepartment of Multidisciplinary Internal MedicineTottori University Faculty of MedicineYonago 683-8504Tottori PrefectureJapan Department of Internal MedicineIrisawa Medical ClinicMatsue 690-0025Shimane PrefectureJapan 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2022年第28卷第19期

页      面：2034-2056页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Department of Multidisciplinary Internal Medicine  Faculty of Medicine  Tottori University 

主　　题：COVID-19 SARS-CoV-2 Pancreatitis Revised atlanta classification Prognosis Etiology 

摘      要：The coronavirus disease 2019(COVID-19)is known to cause gastrointestinal *** studies have revealed COVID-19-attributed acute pancreatitis(AP).However,clinical characteristics of COVID-19-attributed AP remain *** performed a narrative review to elucidate relation between COVID-19 and AP using the PubMed *** basic and pathological reports revealed expression of angiotensin-converting enzyme 2 and transmembrane protease serine 2,key proteins that aid in the entry of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)into the *** experimental and pathological evaluation suggested that SARS-CoV-2 infects human endocrine and exocrine pancreas cells,and thus,SARS-CoV-2 may have a direct involvement in pancreatic ***,systemic inflammation,especially in children,may cause *** of immune mediators associated with AP,including interleukin(IL)-1β,IL-10,interferon-γ,monocyte chemotactic protein 1,and tumor necrosis factor-αare higher in the plasma of patients with COVID-19,that suggests an indirect involvement of the *** real-world settings,some clinical features of AP complicate COVID-19,such as a high complication rate of pancreatic necrosis,severe AP,and high ***,clinical features of COVID-19-attributed AP remain uncertain due to insufficient research on etiologies of ***,high-quality clinical studies and case reports that specify methods for differential diagnoses of other etiologies of AP are needed.