Primary or metastatic lung cancer?Sebaceous carcinoma of the thigh:A case report

作     者：Xiao-Lin Wei Qing Liu Qiang-Lin Zeng Hui Zhou 

作者机构：Department of RespirologyTaikang Sichuan Southwest Hospital Company LimitedChengdu 610095Sichuan ProvinceChina Department of Abdominal OncologyCancer CenterWest China HospitalSichuan UniversityChengdu 610000Sichuan ProvinceChina Department of Respiratory and Critical Care MedicineThe Affiliated Hospital of Chengdu University School of Clinical MedicineChengdu UniversityChengdu 610081Sichuan ProvinceChina 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2022年第10卷第14期

页      面：4586-4593页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Extraocular sebaceous carcinoma Chemotherapy Targeted therapy Radiotherapy Case report 

摘      要：BACKGROUND Sebaceous carcinoma(SC),a malignancy primarily characterized by aggressive growth,affects cutaneous tissues of the periocular *** SC is extremely rare,especially in the extremities,as evidenced by only a handful of reported *** SUMMARY A 65-year-old man presented with a rapidly enlarging swelling on the left inner thigh,which was initially misdiagnosed as a subcutaneous *** lesion had appeared two months prior to *** examination revealed a cauliflower-like swollen content,with an ulcerated and infected mass located on his left *** the same time,we observed solitary nodular lesions in his lungs and brain,with biopsy pathology of the lung lesions found to be consistent with the mass in the *** patient received chemotherapy comprising cis-platinum with fluorouracil,followed by targeted therapy with anlotinib hydrochloride and chemotherapy with vinorelbine,implantation of iodine-125 seeds in the thigh and pulmonary *** initial stage intervention achieved partial *** efficacy of maintenance treatment was evaluated as stable disease after the first 5 cycles;however,the patient developed a new brain lesion after the sixth cycle of treatment,which resulted in progressive disease and he received whole brain gamma knife *** We analyzed the clinical presentation,imaging features,pathology and treatment of a rare case of lung,brain and lymph node metastasis of SC located in the *** is evident that cis-platinum combined with fluorouracil,vinorelbine combined with anlotinib hydrochloride may be an effective therapeutic regimen in advanced ***,brain metastatic lesions should receive early radiotherapy.