Small Interfering RNA Targeting α-Fodrin Suppressing the Immune Response of Sjogren's Syndrome Mice

作     者：Xiao-Lin Sun Chun-Yan Pang Yuan Liu Wei Zhang Yong-Fu Wang Sun Xiao-Lin;Pang Chun-Yan;Liu Yuan;Zhang Wei;Wang Yong-Fu

作者机构：Department of RheumatologyThe First Affiliated Hospital of Baotou Medical CollegeBaotouInner Mongolia 014010China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2018年第131卷第22期

页      面：2752-2754页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

基　　金：supported by grants from the Inner Mongolia Autonomous Region University Scientific Research Project 国家自然科学基金 

主　　题：RNA α-Fodrin 

摘      要：To the Editor:Sjogren s syndrome (SS)is a multisystem chronic autoimmune disease,and mainly affects the lacrimal and salivary glands,leading to ocular and oral dryness.SS is characterized by a large quantity of autoantibodies and involves multiple systems including the lymphatic system,blood,lungs,kidneys, liver,muscles,and joints.Late complications include interstitial pulmonary fibrosis,peripheral neuropathy,tracheobronchial sicca, blindness,arthralgia,oral candidiasis,and lymphoma.The main histopathological feature of SS is lymphocytic infiltration of the exocrine glands,resulting in acinar cell death,probably through apoptosis.[1]The exact etiology and pathogenesis of SS are still not clear.