A　STUDY　ON　DNA　ADDUCTION　WITH　NICOTINE－DERIVED　NITROSAMINE　BY　ACCELERATOR　MASS　SPECTROMETRY

作     者：Xin Song LI1 Yuan Fang LIU1 Jin Yuan SHI1 xiang Yun WANG1 Ke Xin LIU2 Zhi Yu GUO2 Kun LI2, Chia Erh CHEN2 and Si Xun YUAN3 (1Department of Technical Physics, 2Institute of Heavy Ion Physics,3Department of Archaeology, Peking University, Beijing l0087 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：1994年第5卷第10期

页      面：873-876页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070302[理学-分析化学] 0703[理学-化学] 

主　　题：DNA STUDY WITH ACCELERATOR ADDUCTION 

摘      要：DNA adduction with nicotine-derived nitrosamine, 4-(methylnitrosamino)-1-(3- pyridy1)-1 -butanone (NNK) in mice at doses equivalent to human exposure has been studied using 14C-label by accelerator mass spectrometry(AMS). A detection limit of DNA adducts of 1 adduct Per 1010 nucleotides has been achieved. This sensitivity of AMS measurement is 3 or more orders of magnitude improved than that of *** of DNA adducts is linearly dependent on dose down to an exposure of 100 ng Per kg of body weight .The ultimate cheeical form of carcinogen NNK binding to DNA is speculated.