Effect of captopril on myocardial energy metabolism in chronic pressure overload rats
Effect of captopril on myocardial energy metabolism in chronic pressure overload rats作者机构：Department of Cardiology 252 Hospital of Chinese PLA Baoding 071000 Hebei Province China
出 版 物：《Journal of Geriatric Cardiology》 (老年心脏病学杂志（英文版）)
年 卷 期：2010年第7卷第3期
页 面：176-179页
核心收录：
学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 100704[医学-药物分析学] 1002[医学-临床医学] 07[理学] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种] 10[医学]
基 金：Corresponding author: Dr. Cao Xuebin, MD, Department of Cardiology, 252 Hospital of Chinese PLA, Baoding 071000,Hebei Province,China Email: cxb252@yahoo.com.cn. This study was supported by the National Natural Science Foundation of China (30873398), Research Project of "Eleventh Five-year Plan" for Medical Science Development of PLA(2006MA064) and the Research Project of Hebei Province (06276012D- 114)
主 题：pessure overload myocardial energy metabolism energy-rich phosphate
摘 要：Objective To investigate the effects of captopril on cardiac function and levels of energy-rich phosphates in pressure overload induced left ventricular hypertrophy rats. Methods One hundred and twenty SD rats were randomly divided into three groups： sham operation group （SH group, n=40）,coarctation of abdominal aorta group （CAA group, n=40） and captopril treatment lmg~ 100g1 ~ d-1） group （CAP group, n=40）. Left ventricular end-diastolic pressure （LVEDP）, left venh-icular mass index （LVMI）, levels of energy-rich phosphates and morphological changes of the myocardial mitochondria were compared at the 62 and 82 week after operation. Results At 62 week, in CAA group, LVMI and LVEDP were increased and _ dp/dtmax was decreased, while ATP and ADP were decreased and AMP was increased （P〈0.01）. These changes were much obvious at 8th week （P〈0.01）. Compared with those of CAA group, the parameters of heart function and energy-rich phosphates （ATP, ADP, AMP, TAN） in CAP group were improved significantly（P〈0.01） at the 6th and 8th week. In CAP group, the parameters of heart function and energy-rich phosphates （ADP, AMP, TAN） were much better at 8~ week than those at 6th week. The morphological change of mitochondria was less in CAP group than that in CAA group. Conclusion Captopril significantly improves myocardial energy metabolism in pressure overload rats and protects the function of myocardial mitochondria
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