Epidemiology, clinical characteristics, and treatment of severe fever with thrombocytopenia syndrome
作者机构：State Key Laboratory of Pathogen and BiosecurityBeijing Institute of Microbiology and EpidemiologyBeijing100071China
出 版 物：《Infectious Medicine》 (感染医学（英文）)
年 卷 期：2022年第1卷第1期
页 面：40-49页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：This work was supported by grants from the National Science Fund for Distinguished Young Scholars(No.81825019) the National Key Research and Develop-ment Plan of China(No.2021YFC2300200-02) the China Mega-Project on Infectious Disease Prevention(No.2018ZX10713002)
主 题：SFTS Epidemiology Transmission Risk factors Treatment
摘 要：Severe fever with thrombocytopenia syndrome(SFTS)is an emerging tick-borne infectious disease caused by a novel phlebovirus(SFTS virus,SFTSV)in the family Phenuiviridae of the order *** disease causes a wide spectrum of clinical signs and symptoms,ranging from mild febrile disease accompanied by thrombocy-topenia and/or leukocytopenia to hemorrhagic fever,encephalitis,multiple organ failure,and *** was first identified in China and was subsequently reported in South Korea and *** case-fatality rate ranges from 2.7%to 45.7%.Older age has been consistently shown to be the most important predictor of adverse disease *** age exacerbates disease mainly through dysregulation of host immune cells and uncontrolled inflammatory ***-to-human transmission is the primary route of human infection with SFTSV,and Haemaphysalis longicornis is the primary tick vector of *** its high case-fatality rate,vaccines and an-tiviral therapies for SFTS are not currently *** therapeutic efficacies of several antiviral agents against SFTSV are currently being *** was initially identified as a potential antiviral therapy for SFTS but was subsequently found to inefficiently improve disease outcomes,especially among patients with high viral ***(T705)decreased both time to clinical improvement and mortality when administered early in patients with low viral ***-inflammatory agents including corticosteroids have been proposed to play therapeutic ***,the efficacy of other therapeutic modalities,such as convalescent plasma,is not yet clear.
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