Intervening pyruvate carboxylase stunts tumor growth by strengthening anti-tumor actions of tumor-associated macrophages

作     者：Yuxin Shu Nanfei Yang Nan Cheng Zhengyun Zou\Wenlong Zhang Yuncheng Bei Qian Shi Menghao Qin Wei-Guo Zhu Pingping Shen 

作者机构：State Key Laboratory of Pharmaceutical Biotechnology and The Comprehensive Cancer CenterNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolSchool of Life SciencesNanjing UniversityNanjing 210023PR Chino Guangdong Key Laboratory of Genome Instability and Human DiseaseShenzhen University International Cancer CenterDepartment of Biochemistry and Molecular BiologyShenzhen UniversityShenzhen 518060PR China Department of Cellular and Integrative PhysiologyThe University of Texas Health Science Center at San Antonio7703 Floyd Curl DriveSan AntonioTX 78229-3904USA 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2022年第7卷第3期

页      面：607-609页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：strengthening clinical rational 

摘      要：Dear Editor,Tumor-associated macrophages(TAMs)are critical pro-tumor immunocytes and depletion of TAMs has been exploited for cancer therapy.1 However,the phenotypes and functions of TAMs are plastic,TAMs can also be effector cells by engulfing tumor cells and recruiting cytotoxic T cells,thus shaping the actions of TAMs is more scientific rational than depleting them indiscriminately.2 To promote the entry of reorienting TAMs into the clinical treatments of tumors,it is essential to explore the underline mechanisms controlling the anti-and pro-tumor activities of TAMs.