Effects of anti-TNF biologic drugs on uveitis severity in Behcet patients: systematic review and Meta-analysis

作     者：Somayeh Abolhasani Alireza Khabbazi Foroogh Hosseini Shiva Gholizadeh-Ghaleh Aziz Shahriar Alipour 

作者机构：Department of BiochemistryFaculty of MedicineUrmia University of Medical SciencesUrmia 5111Iran Student Research CommitteeUrmia University of Medical SciencesUrmia 5111Iran Connective Tissue Diseases Research CenterTabriz University of Medical ScienceTabriz 4766Iran Department of BiochemistryFaculty of MedicineTabriz University of Medical SciencesTabriz 4766Iran 

出 版 物：《International Journal of Ophthalmology(English edition)》 (国际眼科杂志（英文版）)

年 卷 期：2022年第15卷第5期

页      面：813-819页

核心收录：

学科分类：1002[医学-临床医学] 100212[医学-眼科学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：anti-TNF drugs Behcet’s disease infliximab uveitis visual acuity 

摘      要：AIM:To investigate effects of anti-TNF biologic drugs on uveitis severity(comparing visual acuity log MAR levels) in Behcet ***:Three databases Pub Med, Scopus, and the Web of Science were searched for qualified papers focusing on the anti-TNF-α factors treatment in Behcet’s disease(BD)-associated uveitis. Studies that were designed pre and post anti-TNF drug treatment, were selected. After determining the search strategy for this study, the relevant data were extracted. RESULTS:The initial search was performed in the target databases and a total of about 1458 articles were found. Fifteen articles were selected for systematic review and only 12 of them had inclusion criteria for Meta-analysis(with visual acuity data). The mean dose of prednisolone before and after biological treatments was reported in 5 studies(28.56 and 7.56 mg/kg, respectively). Also, the preliminary results indicate a significant reduction in visual acuity log MAR levels(MD=-1.5 IU/L, 95%CI:-2.1,-0.01).CONCLUSION:Biological drugs significantly reduce the dose of prednisolone and affect visual acuity values.