Security breach:peripheral nerves provide unrestricted access for toxin delivery into the central nervous system

作     者：Igor Lupinski Allison SLiang Randall D.McKinnon Igor Lupinski;Allison S.Liang;Randall D.McKinnon

作者机构：Department of Neurosurgery and MemberThe Cancer Institute of New JerseyRutgers-Robert Wood Johnson Medical SchoolPiscatawayNJUSA 

出 版 物：《中国神经再生研究：英文版》 (Neural Regeneration Research)

年 卷 期：2023年第18卷第1期

页      面：64-67页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by grants from the New Jersey Commission on Spinal Cord Research (05-3047 11-015) 

主　　题：amyotrophic lateral sclerosis bioaccumulation neurodegeneration neuropathology neurotoxins peripheral nerves retrograde transport retrotoxicity suicide transport 

摘      要：We explore the hypothesis that a potential explanation for the initiation of motor neuron disease is an unappreciated vulnerability in central nervous system defense,the direct delivery of neurotoxins into motor neurons via peripheral nerve retrograde *** further suggests a mechanism for focal initiation of neuro-degenerative diseases in general,with subsequent spread by network degeneration as suggested by the Frost-Diamond *** propose this vulnerability may be a byproduct of vertebrate evolution in a benign aquatic environment,where external surfaces were not exposed to concentrated neurotoxins.