Crosslink between mutations in mitochondrial genes and brain disorders:implications for mitochondrial-targeted therapeutic interventions

作     者：Jaspreet Kalra Jaspreet Kalra

作者机构：Department of PharmacologyISF College of PharmacyGhal KalanMogaPunjabIndia Department of Molecular Physiology and Biological PhysicsUniversity of VirginiaCharlottesvilleVAUSA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2023年第18卷第1期

页      面：94-101页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

主　　题：adenosine-triphosphate deficiency mitochondrial fission/fusion mitochondrial mutations neurodegenerative disorders oxidative phosphorylation therapeutic interventions 

摘      要：At the present,association of mitochondrial dysfunction and progression of neurological disorders has gained significant *** in mitochondrial network dynamics,point mutations,deletions,and interaction of pathogenomic proteins with mitochondria are some of the possible underlying mechanisms involved in these neurological *** genetics,defects in mitochondrial oxidative phosphorylation machinery,and reactive oxygen species production might share common crosstalk in the progression of these neurological *** is of significant interests to explore and develop therapeutic strategies aimed at correcting mitochondrial *** review provided insights on mitochondrial dysfunction/mutations involved in the progression of Alzheimer’s disease,Huntington’s disease,and epilepsy with a special focus on Parkinson’s disease *** with the deleterious effects of mitochondrial mutations in aforesaid neurological disorders,this paper unraveled the available therapeutic strategy,specifically aiming to improve mitochondrial dysfunction,drugs targeting mitochondrial proteins,gene therapies aimed at correcting mutant mtDNA,peptide-based approaches,and lipophilic cations.