Risk Factors for Severity and Mortality in Adult Patients Confirmed with COVID-19 in Sierra Leone: A Retrospective Study

作     者：Bo Tu Sulaiman Lakoh Biao Xu Marta Lado Reginald Cole Fang Chu Susan Hastings-Spaine Mohamed Bole Jalloh Junjie Zheng Weiwei Chen Stephen Sevalie Bo Tu;Sulaiman Lakoh;Biao Xu;Marta Lado;Reginald Cole;Fang Chu;Susan Hastings-Spaine;Mohamed Bole Jalloh;Junjie Zheng;Weiwei Chen;Stephen Sevalie

作者机构：Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China College of Medicine and Allied Health SciencesUniversity of Sierra LeoneFreetownSierra Leone Joint Medical UnitRepublic of Sierra Leone Armed Forces34 Military Hospital Wilberforce FreetownFreetownSierra Leone Partners In HealthSierra Leone 

出 版 物：《Infectious Diseases & Immunity》 (感染性疾病与免疫（英文）)

年 卷 期：2022年第2卷第2期

页      面：83-92页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：This work was supported by the National Grand Program on Key Infectious Disease(No.2018ZX10103002-001-007) the Biosafety Special Program(No.19SWAQ 13) 

主　　题：COVID-19 Clinical type Dexamethasone Risk factor 

摘      要：Background:The coronavirus disease 2019(COVID-19)is a highly infectious respiratory *** is no recommended antiviral treatment approved for COVID-19 in Sierra Leone,and supportive care and protection of vital organ function are performed for the *** study summarized the clinical characteristics,drug treatments,and risk factors for the severity and prognosis of COVID-19 in Sierra Leone to provide evidence for the treatment of ***:Data of 180 adult COVID-19 patients from the 34th Military Hospital in Freetown Sierra Leone between March 31,2020 and August 11,2020 were retrospectively *** with severe and critically ill are classified in the severe group,while patients that presented asymptomatic,mild,and moderate disease were grouped in the non-severe *** clinical and laboratory information was retrospectively collected to assess the risk factors and treatment strategies for severe *** information,travel history,clinical symptoms and signs,laboratory detection results,chest examination findings,therapeutics,and clinical outcomes were collected from each case *** logistic analysis was adopted to identify the risk factors for ***,the clinical efficacy of dexamethasone treatment was ***:Seventy-six(42.22%)cases were confirmed with severe COVID-19,while 104 patients(57.78%)were divided into the non-severe ***(56.67%,102/180)and cough(50.00%,90/180)were the common symptoms of *** death rate was 18.89%(34/180),and severe pneumonia(44.12%,15/34)and septic shock(23.53%,8/34)represented the leading reasons for *** older age population,a combination of hypertension and diabetes,the presence of pneumonia,and high levels of inflammatory markers were significantly associated with severity of COVID-19 development(P0.05 for all).Altered level of consciousness[odds ratio(OR)=56.574,95%confidence interval(CI)5.645–566.940,P=0.001],high levels of n