Utilizing 3D bioprinted platelet-rich fibrin-based materials to promote the regeneration of oral soft tissue

作     者：Ke Yi Qing Li Xiaodong Lian Yapei Wang Zhihui Tang 

作者机构：Second Clinical DivisionPeking University School and Hospital of StomatologyBeijing 100101China National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China Center of Digital DentistryPeking University School and Hospital of StomatologyBeijing 100081China Department of ChemistryRenmin University of ChinaBeijing 100872China 

出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)

年 卷 期：2022年第9卷第1期

页      面：234-246页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程] 

基　　金：supported by the National Key Research and Development Program of China(2017YFA0701302 PKUSS20200113) 

主　　题：injectable platelet-rich fibrin 3D bioprinting oral soft tissue engineering regenerative medicine 

摘      要：Oral soft tissue defects remain difficult to treat owing to the limited efficacy of available treatment *** the injectable platelet-rich fibrin(i-PRF)is a safe,autologous source of high levels of growth factors that is often employed to promote the regeneration of oral soft tissue,its effectiveness is restrained by difficulties in intraoperative shaping together with the burst-like release of growth *** herein sought to develop a bioactive bioink composed of i-PRF,alginate and gelatin capable of promoting the regeneration of the oral soft *** bioink was successfully applied in 3D bioprinting and exhibited its ability to be shaped to individual patient ***,we were also able to significantly prolong the duration of multiple growth factors release as compared to that observed for *** growth factor bioavailability was further confirmed by the enhanced proliferation and viability of printed gingival *** deployed in vivo in nude mice,this bioink was further confirmed to be biocompatible and to drive enhanced angiogenic ***,these data thus confirmthe successful production of an i-PRF-containing bioink,which is suitable for the individualized promotion of the regeneration of oral soft tissue.