The interplay between inflammation,immunity and commensal microflora in glaucomatous neurodegeneration

作     者：Christin Henein Peng T.Khaw 

作者机构：National Institute for Health Research Biomedical Research Centre for OphthalmologyMoorfields Eye Hospital and UCL Institute of OphthalmologyLondonUK School of PharmacyUniversity College LondonLondonUK 

出 版 物：《Annals of Eye Science》 (眼科学年鉴（英文）)

年 卷 期：2019年第4卷第1期

页      面：37-40页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Helen Hamlyn Trust Michael and Ilse Katz Foundation Medical Research Council, MRC Fight for Sight UK UCL Institute of Ophthalmology, University College London Moorfields Eye Hospital NHS Foundation Trust National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology Moorfields Eye Charity 

主　　题：glaucoma immunity inflammation 

摘      要：The immensely diverse and rich human gut microbiome has a huge potential to impact health and disease(1).Gut microbiome dysbiosis has been associated with gastro-intestinal inflammatory conditions and extra-intestinal disorders;such as stroke,depression,neurodegenerative,cardiovascular and metabolic disorders(2-6).In the September 2018 issue of nature communications,Chen and colleagues report the findings from a study that found commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma,in mouse glaucoma models(7).