Serologic, endoscopic and pathologic findings in pediatric celiac disease: A single center experience in a low/middle income country
作者机构：Department of PediatricsFaculty of Medicine Kasr Al AinyCairo UniversityCairo 12411Egypt Department of PathologyCairo UniversityCairo 11562Egypt
出 版 物：《World Journal of Clinical Pediatrics》 (世界临床儿科杂志)
年 卷 期：2022年第11卷第3期
页 面：295-306页
学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学]
主 题：Typical Atypical celiac disease Celiac serology Marsh-Oberhuber histopathology
摘 要：BACKGROUND Studies in Africa,Asia,and Latin America are needed to provide a comprehensive picture of the global incidence of celiac disease(CD).AIM To describe the serology,endoscopic and histological findings in typical and atypical presentations of pediatric CD at a tertiary referral hospital in an African low/middle income country(LMIC).METHODS This observational study was conducted on 199 patients with CD from 2010 to *** patients were divided into typical and atypical groups according to the presenting symptoms including 120 and 79 patients ***,upper gastrointestinal endoscopy with duodenal biopsy were performed for patients who had symptoms suggestive of *** severity of the intestinal damage was graded according to the histo-pathologic Marsh-Oberhuber *** Chronic diarrhea was the main intestinal presentation in the typical *** was the most common extraintestinal symptom in both the typical and atypical ***-Oberhuber type 3b and 3c was significantly higher in the seropositive patients with a P value of 0.007.A significant correlation was observed between the histological grade of the biopsied duodenal mucosa and the clinical presentation(P0.001).Age was significantly higher in the atypical group(P value0.001).CONCLUSION Although typical CD was observed in 120 patients in this study,the clinical variability of the condition was frequently *** only was a significant predictor for the appearance of atypical ***,CD presentations in LMIC are not different from industrialized countries.
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