*** co-receptor CD36 as a target in regulation of subretinal inflammation
作者机构：Department of OphthalmologyHôpital Maisonneuve-Rosement Research CentreUniversitéde MontréalMontrealCanada
出 版 物：《Annals of Eye Science》 (眼科学年鉴（英文）)
年 卷 期：2018年第1期
页 面：412-412页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：CD36 subretinal inflammation age-related macular degeneration
摘 要：Subretinal inflammation plays a critical role in retinal degenerative *** activated macrophages have been shown to play a key role in the progression of retinopathies and specifically in age-related macular degeneration,little is known about the mechanisms involved in the loss of photoreceptors leading to vision *** our study on retinal damages induced by photo-oxidative stress,we have observed that CD36-deficient mice featured less subretinal macrophage accumulation with attenuated photoreceptor degeneration compared to wild-type(WT)*** with CD36-selective azapeptide ligand(labelled MPE-001)as modulator of the inflammatory environment of the retina reduced subretinal macrophage/activated microglia accumulation with preservation of photoreceptor layers and function assessed by ERG in WT,in a CD36-dependent *** azapeptide modulated the transcriptome of subretinal macrophage/activated microglia by reducing pro-inflammatory *** isolated macrophages,the CD36-selective azapeptide induced dissociation of the CD36-TLR2/6 heterodimer complex(using FRET)altering the TLR2 signaling pathway,thus decreasing NF-κB activation and inflammasome *** azapeptide also incurred cytoprotection against photoreceptor apoptosis elicited by activated *** findings suggest that the azapeptide as ligand of co-receptor CD36 decreases the inflammatory response by modulating CD36-TLR2/6 complex signaling pathway in macrophages,and suggests its potential application in the treatment of retinal degenerative diseases.
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