Spinal fixation after laminectomy in pigs prevents postoperative spinal cord injury

作     者：Emma M.H.Slot Bart de Boer Saskia Redegeld Sander van Thoor Nizar Moayeri Willem-Bart Slooff Irene A.Schaafsma Björn Meij Tristan P.C.van Doormaal Emma M.H.Slot;Bart de Boer;Saskia Redegeld;Sander van Thoor;Nizar Moayeri;Willem-Bart Slooff;Irene A.Schaafsma;Bj?rn Meij;Tristan P.C.van Doormaal

作者机构：Department of Neurology and NeurosurgeryUniversity Medical Center UtrechtUtrechtThe Netherlands Department of NeurosurgeryElizabeth TweeSteden HospitalTilburgThe Netherlands Brain Technology InstituteUtrechtThe Netherlands Department of Clinical SciencesFaculty of Veterinary MedicineUtrecht UniversityUtrechtThe Netherlands Department of NeurosurgeryClinical Neuroscience CenterUniversity Hospital ZurichZurichSwitzerland 

出 版 物：《Animal Models and Experimental Medicine》 (动物模型与实验医学（英文）)

年 卷 期：2022年第5卷第2期

页      面：153-160页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：supported by a research grant from ZonMw(114024064)。 

主　　题：fixation i nterlaminar decompression medical device model spinal cord injury 

摘      要：Background:A safe,effective,and ethically sound animal model is essential for preclinical research to investigate spinal medical devices.We report the initial failure of a porcine spinal survival model and a potential solution by fixating the spine.Methods:Eleven female Dutch Landrace pigs underwent a spinal lumbar interlaminar decompression with durotomy and were randomized for implantation of a medical device or control group.Magnetic resonance imaging(MRI)was performed before termination.Results:Neurological deficits were observed in 6 out of the first 8 animals.Three of these animals were terminated prematurely because they reached the predefined humane endpoint.Spinal cord compression and myelopathy was observed on postoperative MRI imaging.We hypothesized postoperative spinal instability with epidural hematoma,inherent to the biology of the model,and subsequent spinal cord injury as a potential cause.In the subsequent 3 animals,we fixated the spine with Lubra plates.All these animals recovered without neurological deficits.The extent of spinal cord compression on MRI was variable across animals and did not seem to correspond well with neurological outcome.Conclusion:This study shows that in a porcine in vivo model of interlaminar decompression and durotomy,fixation of the spine after lumbar interlaminar decompression is feasible and may improve neurological outcomes.Additional research is necessary to evaluate this hypothesis.