Small nucleolar RNA host gene 3 functions as a novel biomarker in liver cancer and other tumour progression
作者机构：State Key Laboratory for Diagnosis and Treatment of Infectious DiseasesNational Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2022年第28卷第16期
页 面：1641-1655页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by the National Science and Technology Major Project of China No. 2018ZX10302206 and 2017ZX10202203
主 题：Small nucleolar RNA host gene 3 Long noncoding RNAs,Biomarker Clinical characters Molecular mechanism Competing endogenous RNA Liver cancer
摘 要：Cancer has become the most life-threatening disease in the *** in and aberrant expression of genes encoding proteins and mutations in noncoding RNAs,especially long noncoding RNAs(lncRNAs),have significant effects in human *** have no protein-coding ability but function extensively in numerous physiological and pathological *** nucleolar RNA host gene 3(SNHG3)is a novel lncRNA and has been reported to be differentially expressed in various tumors,such as liver cancer,gastric cancer,and ***,the interaction mechanisms for the regulation between SNHG3 and tumor progression are poorly *** this review,we summarize the results of SNHG3 studies in humans,animal models,and cells to underline the expression and role of SNHG3 in ***3 expression is upregulated in most tumors and is detrimental to patient ***3 expression in lung adenocarcinoma remains ***,SNHG3 affects oncogenes and tumor suppressor genes through various mechanisms,including competing endogenous RNA effects.A deeper understanding of the contribution of SNHG3 in clinical applications and tumor development may provide a new target for cancer diagnosis and treatment.
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