New insights in diagnosis and treatment of gastroenteropancreatic neuroendocrine neoplasms

作     者：Feng Yin Zi-Hao Wu Jin-Ping Lai 

作者机构：Department of Pathology and Anatomical SciencesUniversity of MissouriColumbiaMO 65212United States Department of SurgeryUniversity of MissouriColumbiaMO 65212United States Department of PathologyKaiser Permanente Sacramento Medical CenterSacramentoCA 95825United States 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2022年第28卷第17期

页      面：1751-1767页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Gastroenteropancreatic neuroendocrine neoplasms Neuroendocrine tumours Neuroendocrine carcinoma World Health Organization classification Diagnosis Treatment 

摘      要：Gastroenteropancreatic neuroendocrine neoplasms(GEP-NENs)are rare epithelial neoplasms derived from pluripotent endocrine cells along the gastrointestinal tract and ***-NENs are classified into well-differentiated neuroendocrine tumors and poorly differentiated neuroendocrine *** overlapping morphological features,GEP-NENs vary in molecular biology,epigenetic,clinical behavior,treatment response,and prognosis features and remain an unmet clinical *** this review,we introduce recent updates on the histopathologic classification,including the tumor grading and staging system,molecular genetics,and systemic evaluation of the diagnosis and treatment of GEP-NENs at different anatomic sites,together with some insights into the diagnosis of challenging and unusual *** also discuss the application of novel therapeutic approaches for GEP-NENs,including peptide receptor radionuclide therapy,targeted therapy,and immunotherapy with immune checkpoint *** findings will help improve patient care with precise diagnosis and individualized treatment of patients with GEP-NENs.