Diagnosis and treatment of autoimmune retinopathy

作     者：Henry Lin David Dao H.Nida Sen 

作者机构：Laboratory of ImmunologyNational Eye InstituteNational Institutes of HealthBethesdaMarylandUSA 

出 版 物：《Annals of Eye Science》 (眼科学年鉴（英文）)

年 卷 期：2020年第5卷第3期

页      面：56-68页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Autoimmune retinopathy(AIR) cancer-associated retinopathy melanoma-associated retinopathy immunomodulatory therapy 

摘      要：Autoimmune retinopathy(AIR)refers to both paraneoplastic and non-paraneoplastic forms of a rare,acquired retinal degeneration thought to be mediated by the production of antiretinal ***,the mechanisms underlying AIR pathogenesis are incompletely understood,and it remains a diagnosis of exclusion given the lack of definitive testing as well as its protean clinical *** review summarizes the current literature on the epidemiology,diagnosis,and management of AIR,with a focus on non-paraneoplastic disease and the potential role of immunomodulatory therapy.A recent expert consensus statement on diagnosis and management of non-paraneoplastic AIR served as a framework for interpreting the limited data available,a process that was complicated by the small sample sizes,heterogeneity,and retrospective nature of these *** work is needed to characterize AIR patients on the basis of cytokine and immunogenetic profiling;to establish the pathogenicity of antiretinal antibodies;and to standardize treatment regimens as well as assessment of clinical outcomes.