Implication of the LINGO2 gene in the predisposition to movement disorders

作     者：Gita Vita Soraya Zulvikar Syambani Ulhaq Christian Peinado Garcia 

作者机构：Department of BiochemistryFaculty of MedicineHasanuddin UniversityMakassar 90245South SulawesiIndonesia Department of NeurologyFaculty of MedicineHasanuddin UniversityMakassar 90245South SulawesiIndonesia National Research and Innovation Agency(BRIN)Jakarta 10340Indonesia Department of BiochemistryFaculty of Medicine and Health SciencesMaulana Malik Ibrahim State Islamic University of MalangBatu 65151East JavaIndonesia Department of General SurgeryWeston General HospitalGrange RdWeston super Mare BS234QTUK 

出 版 物：《Brain Science Advances》 (神经科学（英文）)

年 卷 期：2021年第7卷第4期

页      面：257-262页

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

主　　题：LINGO2 Parkinson’s disease essential tremor movement disorder 

摘      要：Previous reports on the pathogenesis of age-related movement disorders,such as Parkinson’s disease(PD)and essential tremor(ET),have demonstrated the potential implications of LINGO1(leucine-rich repeat and immunoglobulin domain-containing protein)*** LINGO2 has a high degree of homology with LINGO1,but it is less characterized and the role of LINGO2 in the development of PD/ET remains ***,this metaanalysis was conducted to evaluate the role of LINGO2 in PD/ET pathogenesis.A total of 4 studies,which complied with the Hardy-Weinberg equilibrium,were included in the *** of the pooled odds ratio and confidence interval of the studies were performed for five genetic models,namely:allelic,dominant,recessive,homozygous,and *** significant association was observed between the LINGO2 polymorphism and PD/ET,although subgroup analysis through conventional metaanalysis indicated that the recessive models of rs7033345 and rs10812774 are significantly associated with predisposition to ET in the Asian ***,trial sequential analyses for both polymorphisms were unlikely to reveal any robust ***,studies with larger samples on this association are needed in the future to corroborate our results.