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文献详情 >Cancer biology deciphered by s... 收藏

Cancer biology deciphered by single-cell transcriptomic sequencing

作     者:Yanmeng Li Jianshi Jin Fan Bai Yanmeng Li;Jianshi Jin;Fan Bai

作者机构:Biomedical Pioneering Innovation Center(BIOPIC)School of Life SciencesPeking UniversityBeijing 100871China RIKEN Center for Biosystems Dynamics Research(BDR)6-2-3FuruedaiSuitaOsakaJapan Beijing Advanced Innovation Center for Genomics(ICG)Peking UniversityBeijing 100871China 

出 版 物:《Protein & Cell》 (蛋白质与细胞(英文版))

年 卷 期:2022年第13卷第3期

页      面:167-179页

核心收录:

学科分类:0710[理学-生物学] 0831[工学-生物医学工程(可授工学、理学、医学学位)] 1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 07[理学] 071009[理学-细胞生物学] 100214[医学-肿瘤学] 0703[理学-化学] 0836[工学-生物工程] 10[医学] 

基  金:This work was financially supported by the National Science and Technology Major Project(2019YFC1315702) the Guangdong Province Key Research and Development Program(2019B020226002). 

主  题:single-cell transcriptomic sequencing tumor microenvironment cancer 

摘      要:Tumors are complex ecosystems in which heterogeneous cancer cells interact with their microenvironment composed of diverse immune,endothelial,and stromal cells.Cancer biology had been studied using bulk genomic and gene expression profiling,which however mask the cellular diversity and average the variability among individual molecular programs.Recent advances in single-cell transcriptomic sequencing have enabled a detailed dissection of tumor ecosystems and promoted our understanding of tumorigenesis at single-cell resolution.In the present review,we discuss the main topics of recent cancer studies that have implemented singlecell RNA sequencing(scRNA-seq).To study cancer cells,scRNA-seq has provided novel insights into the cancer stem-cell model,treatment resistance,and cancer metastasis.To study the tumor microenvironment,scRNA-seq has portrayed the diverse cell types and complex cellular states of both immune and non-immune cells interacting with cancer cells,with the promise to discover novel targets for future immunotherapy.

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