Poly(PEGMA) magnetic nanogels:Preparation via photochemical method,characterization and application as drug carrier

作     者：SUN HanWen ZHANG LianYing ZHU XinJun KONG ChunYan ZHANG CunLan YAO SiDe 

作者机构：Department of ChemistryDezhou UniversityDezhou 253023China Shanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201800China 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2009年第52卷第1期

页      面：69-75页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

基　　金：Supported by the Natural Science Foundation of Shandong Province (Grant No. Q2006F01) Scientific and Technological Project of Shandong Province (Grant No. 2007GG3WZ02066) Scientific and Technological Project of Department of Education, Shandong (Grant No. J07WC01) supported by the Key Laboratory of Bio-physics of Shandong Province 

主　　题：magnetic nanogels photochemical polymerization poly(ethylene glycol) methacrylate drug carrier doxorubicin 

摘      要：One-pot synthesis of magnetic nanogels with excellent biocompatibility via the photochemical method is reported in this ***(PEGMA) modified superparamagnetic nanogels(poly(PEGMA) magnetic nanogels) were synthesized by in-situ polymerization using poly(ethylene glycol) methacrylate(PEGMA) as the monomer and N,N -methylene-bis-(acrylamide)(MBA) as the cross-linking agent in magnetite aqueous suspension under UV *** surface functional groups and components of magnetic nanogels were analyzed by Fourier transform infrared spectroscopy(FTIR) and a thermogra-vimetric analyzer(TGA).The results indicated that the poly(PEGMA) magnetic nanogels were synthe-sized successfully by coating poly(PEGMA) on the Fe3O4 nanoparticles under UV irradiation,and the Fe3O4 nanoparticles content in this nanogels was above 50 wt%.The morphology,size,zeta-potential and magnetic property were also *** magnetic nanogels had a nearly spherical shape and core-shell structure,the average size in aqueous system measured by photon correlation spec-troscopy(PCS) was 68.4 nm,which was much bigger than that in the dry state,the nanogels behaved superparamagnetically with saturated magnetization of 58.6 emu/g,and the zeta-potential was-16.3-_17.3 mV at physiological pH(6.8-7.4) which could help to maintain stability in *** preliminary application as drug carrier was made and the doxorubicin-loaded magnetic nanogels had an excellent property in *** experiment indicated that the magnetic nanogel was an ideal candidate carrier in target drug delivery systems and other biomedical application.