A simple,universal and multifunctional template agent for personalized treatment of bone tumors
作者机构：Department of OrthopaedicsThe Fourth Medical CentreChinese PLA General Hospital51 Fucheng RoadHaidian DistrictBeijing100048China Department of Orthopedic Oncology and Spine Tumor CenterChangzheng HospitalSecond Military Medical UniversityShanghai200001China PLA Rocket Force Characteristic Medical CenterBeijing100088China School of MedicineNankai UniversityTianjin300071China
出 版 物：《Bioactive Materials》 (生物活性材料（英文）)
年 卷 期：2022年第7卷第6期
页 面：292-302页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 10[医学]
主 题：Bone tumor Osteosarcoma Polydopamine Photothermal therapy
摘 要：Bone tumors occur in bone or its accessory tissues.Benign bone tumors are easy to cure and have good prognosis,while malignant bone tumors develop rapidly and have poor and high mortality.So far,there is no satisfactory treatment method.Here,we designed a universal template vector for bone tumor therapy that simultaneously meets the needs of bone targeting,tumor killing,osteoclast suppression,and tumor imaging.The template is composed of a polydopamine(PDA)core and a multifunctional surface.PDA has excellent biosafety and photothermal performance.In this study,alendronate sodium(ALN)is grafted to enable its general bone targeting function.PDA core can carry a variety of chemotherapy drugs,and the rich ALN group can carry a variety of metal ions with an imaging function.Therefore,more personalized treatment plans can be designed for different bone tumor patients.In addition,the PDA core enables photothermal therapy and enhanced chemotherapy.Through template drug Doxorubicin(DOX)and template imaging ion Fe(II),we systematically verified the therapeutic effect,imaging effect,and inhibition of bone dissolution of the agent on Osteosarcoma(OS),a primary malignant bone tumor,in vivo.In conclusion,our work provides a more general template carrier for the clinical treatment of bone tumors,through which personalized treatment of bone tumors can be achieved.
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