Electrooxidation-Induced C(sp^(3))-H/C(sp^(2))-H Radical-Radical Cross-Coupling between Xanthanes and Electron-Rich Arenes

作     者：Yuwei Liang Linbin Niu Xing-An Liang Shengchun Wang Pengjie Wang Aiwen Lei Yuwei Liang;Linbin Niu;Xing-An Liang;Shengchun Wang;Pengjie Wang;Aiwen Lei

作者机构：College of Chemistry and Molecular SciencesInstitute for Advanced Studies(IAS)Wuhan UniversityWuhanHubei 430072China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2022年第40卷第12期

页      面：1422-1428页

核心收录：

学科分类：07[理学] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：the National Key R&D Program of China(No.2021YFA1500104) the National Natural Science Foundation of China(No.22031008) the Science Foundation of Wuhan(No.2020010601012192)。 

主　　题：Electrochemistry C-H activation C-C coupling C(sp^(2))-H alkylation Electron-rich arenes 

摘      要：The arylation of C(sp^(3))-H bonds has been a priority research topic in organic synthesis.Minsici reactions have been the powerful methods for C(sp^(3))-C(sp^(2))bonds formation.Despite its mature development,the scopes of arenes are usually suitable for elec-tron-deficient heterocyclic compounds,rather than electron-rich arenes.Herein,we report an electrooxidation-induced alkylation of electron-rich arenes with H_(2) evolution under exogenous oxidant-free conditions,avoiding the utilization of metal catalysts.This pro-tocol is well performed with various electron-rich aniline derivatives and nitrogen-containing heterocyclic compounds.We anticipate that this electro-oxidative C(sp^(3))-H arylation represents an important expansion for the classic arenes alkylation,thereby proving an attractive strategy for the developments of radical cross-coupling chemistry.