Biomaterial scaffolds for clinical procedures in endodontic regeneration
作者机构：Department of StomatologyAffiliated Hospital of Jining Medical UniversityChina Division of EndodonticsDepartment of Oral Biological and Medical SciencesFaculty of DentistryUniversity of British ColumbiaCanada Key Laboratory of Oral DiseaseSchool and Hospital of StomatologyFujian Medical UniversityFuzhouChina Department of EndodonticsStomatology Hospital of Guangzhou Medical UniversityGuangzhouChina Department of EndodonticsThe Dental College of GeorgiaAugusta UniversityAugustaGAUSA
出 版 物：《Bioactive Materials》 (生物活性材料（英文）)
年 卷 期：2022年第7卷第6期
页 面：257-277页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1003[医学-口腔医学] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 10[医学]
主 题：Biomaterials Clinical approach Regenerative endodontics Scaffolds
摘 要：Regenerative endodontic procedures have been rapidly evolving over the past two decades and are employed extensively in clinical endodontics.These procedures have been perceived as valuable adjuvants to conventional strategies in the treatment of necrotic immature permanent teeth that were deemed to have poor prognosis.As a component biological triad of tissue engineering(i.e.,stem cells,growth factors and scaffolds),biomaterial scaffolds have demonstrated clinical potential as an armamentarium in regenerative endodontic procedures and achieved remarkable advancements.The aim of the present review is to provide a broad overview of biomaterials employed for scaffolding in regenerative endodontics.The favorable properties and limitations of biomaterials organized in naturally derived,host-derived and synthetic material categories were discussed.Preclinical and clinical studies published over the past five years on the performance of biomaterial scaffolds,as well as current challenges and future perspectives for the application of biomaterials for scaffolding and clinical evaluation of biomaterial scaffolds in regenerative endodontic procedures were addressed in depth.
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