Porous tantalum structure integrated on Ti6Al4V base by Laser Powder Bed Fusion for enhanced bony-ingrowth implants:In vitro and in vivo validation

作     者：Pengfei Lei Hu Qian Taomei Zhang Ting Lei Yihe Hu Chao Chen Kechao Zhou 

作者机构：Department of Orthopedic SurgeryHunan Engineering Research Center of Biomedical Metal and Ceramic ImplantsXiangya HospitalCentral South UniversityChangsha 410008China Department of Orthopedic SurgeryThe First Affiliated HospitalCollege of MedicineZhejiang UniversityChina State Key Laboratory of Powder MetallurgyCentral South UniversityChangsha410083China 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2022年第7卷第1期

页      面：3-13页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0836[工学-生物工程] 

基　　金：This study was supported by the Natural Science Foundation of Hunan Province,China(Grant No.2019JJ40499) the Scientific Research Project of Health and Family Planning Commission of Hunan Province,China(Grant No.B2019188) the Science and technology Innovation Leading Project for High-tech Industry of Hunan Province(Grant No.2020SK2008) the Major science and technology projects of Changsha City(Grant No.42193) National key research and development project(2018YFB1105504) Natural Science Foundation of China(Grant No.82002277 and 81672656). 

主　　题：Tantalum Ti6Al4V Laser powder bed fusion Orthopedic scaffolds Osteointegration 

摘      要：Despite the widespread application of Ti6Al4V and tantalum(Ta)in orthopedics,bioinertia and high cost limit their further applicability,respectively,and tremendous efforts have been made on the Ti6Al4V-Ta alloy and Ta coating to address these drawbacks.However,the scaffolds obtained are unsatisfactory.In this study,novel high-interface-strength Ti6Al4V-based porous Ta scaffolds were successfully manufactured using Laser Powder Bed Fusion for the first time,in which porous Ta was directly manufactured on a solid Ti6Al4V substrate.Mechanical testing revealed that the novel scaffolds were biomechanically compatible,and the interfacial bonding strength was as high as 447.5 MPa.In vitro biocompatibility assay,using rat bone marrow mesenchymal stem cells(r-BMSCs),indicated that the novel scaffolds were biocompatible.Alkaline phosphatase and mineralized nodule determination demonstrated that the scaffolds favored the osteogenic differentiation of r-BMSCs.Moreover,scaffolds were implanted into rabbits with femur bone defects,and imaging and histological evaluation identified considerable new bone formation and bone ingrowth,suggesting that the scaffolds were well integrated with the host bone.Overall,these results demonstrated good mechanical compatibility,biocompatibility,and osteointegration performance of the novel Ti6Al4V-based porous Ta scaffold,which possesses great potential for orthopedic clinical applications.