ssDNA functionalized nanodiamonds for uranium decorporation

作     者：Qinglong Yan Yu Miao Xiaomei Wang Jifei Ma Juan Diwu Ying Zhu Shuao Wang Chunhai Fan Qinglong Yan;Yu Miao;Xiaomei Wang;Jifei Ma;Juan Diwu;Ying Zhu;Shuao Wang;Chunhai Fan

作者机构：Interdisciplinary Research CenterShanghai Synchrotron Radiation FacilityZhangjiang LaboratoryShanghai Advanced Research InstituteChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 201210China Shanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201800China State Key Laboratory of Radiation Medicine and ProtectionSchool for Radiological and Interdisciplinary Sciences(RAD-X)and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSoochow UniversitySuzhou 215123China School of Chemistry and Chemical EngineeringFrontiers Science Center for Transformative Molecules and National Center for Translational MedicineShanghai Jiao Tong UniversityShanghai 200240China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2022年第33卷第7期

页      面：3570-3572页

核心收录：

学科分类：081702[工学-化学工艺] 07[理学] 070205[理学-凝聚态物理] 08[工学] 0817[工学-化学工程与技术] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学] 

基　　金：supported by grants from the National Natural Science Foundation of China(Nos.82050005,21976127,22022410) the Youth Innovation Promotion Association of CAS(No.2016236) the Natural Science Foundation of Jiangsu Province(Nos.BK20190044,BK20210736) funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD) the China Postdoctoral Science Foundation(No.2020M681431) 

主　　题：Nanodiamond ssDNA Uranium Decorporation 

摘      要：The hunt for agents that are suitable for actinide decorporation to reduce the whole-body load of actinide in accidental internal exposure is the ever-lasting goal in radiation protection and medical treatment in nuclear *** current decorporation agents can be categorized as two groups,one is the molecular ligands,and the other is the nanoparticles decorated with molecular *** in this work,functional nanodiamonds(fN Ds)with ss DNA(the endogenous biomacromolecule rich in phosphate groups)loaded on the NDs is reported,which poses good uranyl adsorption selectivity,high cellular uptake,fast excretion,and effective decorporation of uranyl from rat renal proximal tubular epithelial cells(NRK-52E).All those results corroborate that f NDs can potentially serve as a brand new family of chelators for actinide decorporation.