Pharmacological manipulation of macrophage autophagy effectively rejuvenates the regenerative potential of biodegrading vascular graft in aging body
作者机构：State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi Key Laboratory of StomatologyDepartment of Oral&Maxillofacial SurgerySchool of StomatologyThe Fourth Military Medical UniversityXi’anShaanxiChina School&Hospital of StomatologyTongji UniversityShanghai Engineering Research Center of Tooth Restoration and Regeneration399 Middle Yanchang RoadShanghai 200072China
出 版 物：《Bioactive Materials》 (生物活性材料（英文）)
年 卷 期：2022年第7卷第5期
页 面：283-299页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1006[医学-中西医结合] 1002[医学-临床医学] 0805[工学-材料科学与工程（可授工学、理学学位）] 10[医学] 100602[医学-中西医结合临床]
基 金：financially supported by National Natural Science Foundation of China(No.82071132 81422008 81771040).
主 题：Autophagy Macrophages Inflammation Aging Fast-degradation materials
摘 要：Declined regenerative potential and aggravated inflammation upon aging create an inappropriate environment for arterial regeneration.Macrophages are one of vital effector cells in the immune microenvironment,especially during biomaterials mediated repairing process.Here,we revealed that the macrophage autophagy decreased with aging,which led to aggravated inflammation,thereby causing poor vascular remodeling of artificial grafts in aging body.Through loading the autophagy-targeted drugs,rapamycin and 3-MA(3-methyladenine),in PCL(polycaprolactone)sheath of the PGS(poly glycerol sebacate)-PCL vascular graft,the essential role of macrophage autophagy was confirmed in regulating macrophage polarization and biomaterial degradation.Moreover,the utilization of rapamycin promoted anti-inflammatory polarization of macrophage by activating autophagy,which further promoted myogenic differentiation of vascular progenitor cells and accelerated endothelialization.Our study elucidated the contribution of pharmacological manipulation of macrophage autophagy in promoting regeneration of small caliber artery,which may pave a new avenue for clinical translation of vascular grafts in aging body.
维普期刊数据库