Helical Nonfouling Polypeptides for Biomedical Applications

作     者：Chong Zhang Hua Lu Chong Zhang;Hua Lu

作者机构：Department of Biomedical EngineeringSouthern University of Science and TechnologyShenzhen 518055China Beijing National Laboratory for Molecular SciencesCenter for Soft Matter Science and EngineeringKey Laboratory of Polymer Chemistry and Physics of Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China 

出 版 物：《Chinese Journal of Polymer Science》 (高分子科学（英文版）)

年 卷 期：2022年第40卷第5期

页      面：433-446页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 07[理学] 08[工学] 070303[理学-有机化学] 0703[理学-化学] 0836[工学-生物工程] 

基　　金：financially supported by the National Key Research and Development Program of China (No. 2019YFA0904203) the National Natural Science Fund for Distinguished Young Scholars (No. 22125101) 

主　　题：Poly(α-amino acid) Polypeptide Helix Nonfouling PEPylation 

摘      要：Synthetic polypeptides,also known as poly(α-amino acid)s(PαAAs),are biomimetic and biodegradable polymers holding great potential for a variety of biomedical applications.Possessing the same peptide bonds as natural proteins,polypeptides can also adopt typical well-defined secondary structures includingα-helix,which have been shown to significantly impact the physicochemical properties and biological outcomes of materials.In this feature article,we review the state-of-the-art progresses ofα-helical polypeptides for biomedical applications,with a special emphasis on the manipulation of helix-to-coil dynamic transition,conformation-associated anti-biofouling coatings,cellular uptake regulation,and reducing immunogenicity of polypeptide-protein conjugates.Finally,perspectives on outstanding challenges remained in this field and some important future directions are discussed.