Trauma-induced pulmonary thromboembolism:What's update?

作     者：Yu-Hong Mi Ming-Ying Xu Yu-Hong Mi;Ming-Ying Xu

作者机构：Emergency and Critical Care CenterBeijing Anzhen HospitalCapital Medical UniversityBeijing Institute of HeartLung and Blood Vascular DiseaseBeijing100029China 

出 版 物：《Chinese Journal of Traumatology》 (中华创伤杂志（英文版）)

年 卷 期：2022年第25卷第2期

页      面：67-76页

核心收录：

学科分类：0403[教育学-体育学] 1002[医学-临床医学] 10[医学] 

基　　金：This study was funded by Chaoyang District Bureau of Science and Technology and Information Technology(Bureau of Big Data).Contract no.CYSF 2049. 

主　　题：Wounds and injuries Pulmonary thromboembolism Venous thromboembolism Deep venous thrombosis Etiology Treatment Prevention 

摘      要：Trauma-induced pulmonary thromboembolism is the second leading cause of death in severe trauma patients. Primary fibrinolytic hyperactivity combined with hemorrhage and consequential hypercoagulability in severe trauma patients create a huge challenge for clinicians. It is crucial to ensure a safe anticoagulant therapy for trauma patients, but a series of clinical issues need to be answered first, for example, what are the risk factors for traumatic venous thromboembolism? How to assess and determine the status of coagulation dysfunction of patients? When is the optimal timing to initiate pharmacologic prophylaxis for venous thromboembolism? What types of prophylactic agents should be used? How to manage the anticoagulation-related hemorrhage and to determine the optimal timing of restarting chemoprophylaxis? The present review attempts to answer the above questions.