Malaria from hyperendemicity to elimination along international borders in Yunnan, China during 2003‒2020: a case study

作     者：Hui Liu Yaowu Zhou Yan Deng Zurui Lin Canglin Zhang Qiyan Chen Chun Wei Kaixia Duan Peng Tian Hongning Zhou Jianwei Xu Hui Liu;Yaowu Zhou;Yan Deng;Zurui Lin;Canglin Zhang;Qiyan Chen;Chun Wei;Kaixia Duan;Peng Tian;Hongning Zhou;Jianwei Xu

作者机构：Yunnan Institute of Parasitic DiseasesYunnan Provincial Centre of Malaria ResearchYunnan Provincial Key Laboratory of Vector-Borne Diseases Control and ResearchYunnan Institute of Parasitic Diseases Innovative Team of Key Techniques for Vector Borne Disease Control and PreventionTraining Base of International Scientific Exchange and Education in Tropical Diseases for South and Southeast AsiaPuer665000China 

出 版 物：《Infectious Diseases of Poverty》 (贫困所致传染病（英文）)

年 卷 期：2022年第11卷第3期

页      面：69-80页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：This work was supported by the National Natural Science Foundation of China(No.81560543 and 81673113). 

主　　题：Malaria Control Elimination Border area International collaboration Yunnan China 

摘      要：Background: Border malaria is one of the most intractable problems hindering malaria elimination worldwide.Movement of both the human population and anopheline mosquitoes infected with Plasmodium spp.can cause cross-border malaria transmission.The Yunnan border area was still hyperendemic for malaria in the early part of this century.The objective of this case study was to analyze the strategies,interventions and impacts of malaria control and elimination in the Yunnan border area.Main text: A total of 10,349 malaria cases and 17.1 per 10,000 person-years of annual parasite incidence(API)were reported in the border area in 2003.Based on natural village-based stratification,integrated interventions,including mass drug administration for radical cures and preventive treatment,clinically presumptive treatment of all febrile patients for malaria and indoor residual spraying or dipping bed nets with insecticides were successfully carried out from 2003 to 2013.The overall API was reduced to 0.6 per 10,000 person-years by 2013,while effective cross-border collaboration interventions dramatically reduced the malaria burden in the neighbouring border areas of Myanmar.From 2014 forward,the comprehensive strategy,including universal coverage of surveillance to detect malaria cases,a rapid response to possible malaria cases and effective border collaboration with neighbouring areas,successfully eliminated malaria and prevented reintroduction of malaria transmission in the Yunnan border area.Conclusions: In Yunnan malaria burden has successfully reduced by dynamically accurate stratification and comprehensive interventions;and then the region achieved elimination and prevented reintroduction of malaria transmission through intensive surveillance,rapid response and border collaboration.Other border areas should perform their own intervention trials to develop their own effective strategy.