Ungulate bocaparvovirus 4 and rodent bocavirus are different genotypes of the same species of virus

作     者：Wenqiao He Yuhan Gao Yuqi Wen Xuemei Ke Zejin Ou Jiaqi Fu Mingji Cheng Yun Mo Qing Chen Wenqiao He;Yuhan Gao;Yuqi Wen;Xuemei Ke;Zejin Ou;Jiaqi Fu;Mingji Cheng;Yun Mo;Qing Chen

作者机构：Department of EpidemiologySchool of Public HealthGuangdong Provincial Key Laboratory of Tropical Disease ResearchSouthern Medical UniversityGuangzhou510515China Xiamen Center for Disease Control and PreventionXiamen361000China 

出 版 物：《Virologica Sinica》 (中国病毒学（英文版）)

年 卷 期：2022年第37卷第2期

页      面：215-222页

核心收录：

学科分类：0710[理学-生物学] 090601[农学-基础兽医学] 1001[医学-基础医学(可授医学、理学学位)] 09[农学] 0906[农学-兽医学] 100103[医学-病原生物学] 10[医学] 

基　　金：supported by the Key-Area Research and Development Program of Guangdong Province (no. 2018B020241002) the National Natural Science Foundation of China (no. 81373051)。 

主　　题：Ungulate bocaparvovirus 4 Rodent bocavirus(RoBoV) Genome Rats 

摘      要：Bocaviruses are associated with many human infectious diseases, such as respiratory tract infections, gastroenteritis, and hepatitis. Rats are known to be reservoirs of bocaviruses, including rodent bocavirus and rat bocavirus.Recently, ungulate bocaparvovirus 4, a known porcine bocavirus, has also been found in rats. Thus, investigating bocaviruses in rats is important for determining the origin of the viruses and preventing and controlling their transmission. To the best of our knowledge, no study to date has investigated bocaviruses in the livers of rats. In this report, a total of 624 rats were trapped in southern China between 2014 and 2017. Liver and serum samples from rats were tested for the prevalence of bocaviruses using PCR. Sequences related to ungulate bocaparvovirus 4and rodent bocavirus were detected in both liver and serum samples. Interestingly, the prevalence of ungulate bocaparvovirus 4(reference strain: KJ622366.1) was higher than that of rodent bocavirus(reference strain:KY927868.1) in both liver(2.24% and 0.64%, respectively) and serum samples(2.19% and 0.44%, respectively).The NS1 regions of ungulate bocaparvovirus 4 and rodent bocavirus related sequences displayed over 84% and88% identity at the nucleic acid and amino acid levels, respectively. Furthermore, these sequences had similar genomic structure, genomic features, and codon usage bias, and shared a common ancestor. These viruses also displayed greater adaptability to rats than pigs. Our results suggested that ungulate bocaparvovirus 4 and rodent bocavirus may originate from rats and may be different genotypes of the same bocavirus species.