Modification of Serum Galectin-3 and Reversal of Cardiac Remodeling Following Pediatric Transcatheter Atrial Septal Defect Closure

作     者：Omnia Shafei Alyaa A.Kotby Mona MEl Ganzoury Nevin M.Habeeb Eman Elsayed 

作者机构：Department of PediatricsFaculty of MedicineAin Shams UniversityCairoEgypt Children’s HospitalCardiology UnitAin Shams University HospitalsCairoEgypt 

出 版 物：《Congenital Heart Disease》 (先天性心脏病（英文）)

年 卷 期：2022年第17卷第2期

页      面：173-185页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Percutaneous device closure Galectin-3 cardiac remodeling children atrial septal defect 

摘      要：Objectives:We aimed to evaluate the effect of percutaneous atrial septal defect(ASD)closure in children using right heart indices and serum galectin-3(Gal-3),as potential biomarkers of right heart ***:This case–control prospective study included 40 children with ASD and 25 control *** echocardiographic evaluation was performed before the procedure,as well as 24 h,1 month,and 6 months after *** Gal-3 was measured before,and 1 month after the ***:Serum Gal-3 concentration,right atrial(RA)dimensions,right ventricular(RV)dimensions,indexed RA area,and right index of myocardial performance(RIMP)were significantly increased in children with ASD compared with control subjects while tricuspid annular plane systolic excursion(TAPSE)was significantly *** months after closure,RA,and RV dimensions significantly decreased and RVfunction improved(RIMP decreased and TAPSE increased).Gal-3 oncentration significantly decreased 1 month after ASD closure,but it did not reach normal range compared with control subjects.A positive correlation between Gal-3 and age at closure,RA area,RV dimensions,and RIMP was observed.A positive correlation was observed between the decrease in Gal-3 concentration and the decrease in RA area and RV dimensions 1 month after ASD closure.A significant negative correlation was observed between TAPSE and Gal-3 concentration before and after ***:Percutaneous ASD closure can improve right-sided indices and decrease serum Gal-3 ***-3 can be used as a sensitive biomarker of right heart remodeling,with a decrease in Gal-3 concentration suggesting reversal of maladaptive remodeling.