Patient-derived skin fibroblasts as a model to study frontotemporal lobar degeneration

作     者：Dorit Hoffmann Annakaisa Haapasalo Dorit Hoffmann;Annakaisa Haapasalo

作者机构：A.I.Virtanen Institute for Molecular SciencesUniversity of Eastern FinlandKuopioFinland 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第12期

页      面：2669-2671页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100205[医学-精神病与精神卫生学] 10[医学] 

基　　金：supported by the Sigrid Jusélius Foundation a grant from the Academy of Finland (grant no.315459) 

主　　题：degeneration patients 

摘      要：Frontotemporal lobar degeneration(FTLD)is one of the most common causes of early-onset dementia in patients under the age of 65 years.It is a clinically,genetically,and neuropathologically heterogeneous group of neurodegenerative syndromes,causing atrophy in the temporal and frontal lobes of the brain.This is accompanied by progressive cognitive dysfunction,behavioral changes,difficulties in understanding or producing speech,and often also neuropsychiatric symptoms(Haapasalo and Remes,2015).Moreover,the clinical,genetic,and neuropathological features of FTLD may overlap with those of amyotrophic lateral sclerosis(ALS).Motor dysfunction is commonly present in FTLD patients and a portion of ALS patients experience frontal and temporal lobe dysfunction(Smith et al.,2019).