Natural polymer-derived photocurable bioadhesive hydrogels for sutureless keratoplasty
作者机构：State Key Laboratory of OphthalmologyZhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou510623China
出 版 物：《Bioactive Materials》 (生物活性材料（英文）)
年 卷 期：2022年第7卷第2期
页 面：196-209页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 081702[工学-化学工艺] 08[工学] 0817[工学-化学工程与技术] 0805[工学-材料科学与工程（可授工学、理学学位）]
基 金：supported by National Natural Science Foundation of China(81870633) Guangdong Province Key Field R&D Program(2020B1111150002).
主 题：Bioadhesive hydrogels Photocurable Cornea repair Sutureless keratoplasty
摘 要：Keratoplasty is the gold standard treatment for visual impairment caused by corneal damage.The use of suturing as the bonding method is the source of many complications following keratoplasty.Currently available corneal adhesives do not have both adequate adhesive strength and acceptable biocompatibility.Herein,we developed a photocurable bioadhesive hydrogel which was composed of gelatin methacryloyl and oxidized dextran for sutureless keratoplasty.The bioadhesive hydrogel exhibited high light transmittance,resistance to enzymatic degradation and excellent biocompatibility.It also had higher adhesive strength than commercial adhesives(fibrin glue).In a rabbit model of lamellar keratoplasty,donor corneal grafts could be closely bonded to the recipient corneal bed and remained attached for 56 days by using of this in situ photopolymerized bioadhesive hydrogel.The operated cornea maintained transparent and noninflamed.Sutureless keratoplasty using bioadhesive hydrogel allowed rapid graft re-epithelialization,typically within 7 days.In vivo confocal microscopic and histological evaluation of the operated cornea did not show any apparent abnormalities in terms of corneal cells and ultrastructure.Thus,this bioadhesive hydrogel is exhibited to be an appealing alternative to sutures for keratoplasty and other corneal surgeries.
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