Hypolipidemic effect of chromium-modified enzymatic product of sulfated rhamnose polysaccharide from Enteromorpha prolifera in type 2 diabetic mice

作     者：Xinyu Wang Han Ye Jiefen Cui Yongzhou Chi Ruizhi Liu Peng Wang 

作者机构：College of Food Science and EngineeringOcean University of ChinaQingdao266003China State Environmental Protection Key Laboratory of Estuarine and Coastal EnvironmentBeijing100012China 

出 版 物：《Marine Life Science & Technology》 (海洋生命科学与技术（英文）)

年 卷 期：2022年第4卷第2期

页      面：245-254页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 100602[医学-中西医结合临床] 

基　　金：funded by the Innovation Capability Improvement Project of Shandong(2021TSGC1298) the Qingdao Science and Technology Project(2022) 

主　　题：Sulfated rhamnose polysaccharides Enteromorpha prolifera Chromium Hypolipidemic Type 2 diabetic mice 

摘      要：Sulfated rhamnose polysaccharide(SRP)derived from Enteromorpha prolifera is a metal-ion chelating agent that could potentially be used to treat *** aim of our study was to determine the effect of a variant of SRP on ***,we synthesized and characterized SRPE-3 chromium(III)[SRPE-3-Cr(III)]complex using an enzymatic *** maximum chelation rate was 18.2%under optimal chelating conditions of pH 6.0,time 4 h,and temperature 60°*** transform infrared spectroscopy results showed important sites for Cr(III)-binding were O–H and C=O *** then studied the hypolipidemic effects of SRPE-3-Cr(III)on type 2 diabetes mellitus(T2DM)induced by a high-fat,high-sucrose diet(HFSD).Decreased blood glucose content,body fat ratio,serum TG,TC,LDL-C,and increased serum HDL-C were observed after treatment with SRPE-3-Cr(III).In addition,SRPE-3-Cr(III)significantly reduced leptin,resistin,and TNF-αlevels,and increased adiponectin contents relative to *** results also showed that SRPE-3-Cr(III)could alleviate the HFSD-lesioned ***-3-Cr(III)also improved lipid metabolism via a reduction in aspartate aminotransferase,alanine aminotransferase,fatty acid synthase,and acetyl-CoA carboxylase activities in the ***-3-Cr(III)at low doses exhibited better lipid-lowering activities,hence,could be considered to be a novel compound to treat hyperlipidemia and also act as an anti-diabetic agent.