Nanostructured polyvinylpyrrolidone-curcumin conjugates allowed for kidney-targeted treatment of cisplatin induced acute kidney injury

作     者：Hao Wei Dawei Jiang Bo Yu Dalong Ni Mengting Li Yin Long Paul A.Ellison Cerise M.Siamof Liang Cheng Todd E.Barnhart Hyung-Jun Im Faquan Yu Xiaoli Lan Xiaohua Zhu Qianjun He Weibo Cai 

作者机构：Department of Nuclear MedicineUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China National-Regional Key Technology Engineering Laboratory for Medical UltrasoundGuangdong Key Laboratory for Biomedical Measurements and Ultrasound ImagingSchool of Biomedical EngineeringShenzhen UniversityShenzhen518060China Departments of Radiology and Medical PhysicsUniversity of Wisconsin–MadisonMadisonWI53705USA Department of Nuclear MedicineTongji HospitalTongji Medical CollegeHuazhong University of Science and Technology1095 Jiefang AveWuhan430030China Key Laboratory for Green Chemical Process of Ministry of EducationSchool of Chemical Engineering and PharmacyWuhan Institute of TechnologyWuhan430073China Institute of Functional Nano&Soft Materials(FUNSOM)Collaborative Innovation Center of Suzhou Nano Science and TechnologySoochow UniversitySuzhou215123China University of Wisconsin Carbone Cancer CenterUniversity of Wisconsin–MadisonMadisonWI53705USA 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2023年第19卷第1期

页      面：282-291页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(81601605,21571147,82102121) the Postdoctoral Science Foundation of China(2016M600670) supported by the University of Wisconsin–Madison,the National Institutes of Health(NIBIB/NCI P30CA014520) the Natural Science Foundation of SZU(Grant No.827-000143) the Shenzhen Peacock Plan(KQTD2016053112051497) 

主　　题：Nanomedicine Acute kidney injury Kidney targeting Positron emission tomography(PET)imaging Zirconium-89(^(89)Zr) Nuclear medicine 

摘      要：Acute kidney injury(AKI)leads to unacceptably high mortality due to difficulties in timely intervention and less efficient renal delivery of therapeutic ***,a series of polyvinylpyrrolidone(PVP)-curcumin nanoparticles(PCurNP)are designed to meet the renal excretion threshold(~45 kDa),presenting a controllable delivery nanosystem for kidney *** accumulation of the relatively small nanoparticles,^(89)Zr-PCurNP M10 with the diameter between 5 and 8 nm,is found to be 1.7 times and 1.8 times higher than the accumulation of^(89)Zr-PCurNP M29(20-50 nm)and M40(20-50 nm)as revealed by PET ***,serum creatinine analysis,kidney tissues histology,and tubular injury scores revealed that PCurNP M10 efficiently treated cisplatin-induced ***,PCurNP offers a novel and simple strategy for precise PET image-guided drug delivery of renal protective materials.